Premium
Early Effects of Dietary Soy and Genistein in Rodent Models of Mammary Tumorigenesis
Author(s) -
Simmen Rosalia CM,
Su Ying,
Pabona John Mark M,
Rahal Omar,
Simmons Christian Dupre,
Hennings Leah
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.897.3
Subject(s) - biology , endocrinology , medicine , mammary tumor , genistein , carcinogenesis , mammary gland , wnt signaling pathway , lactation , population , pten , breast cancer , cancer research , cancer , signal transduction , microbiology and biotechnology , pi3k/akt/mtor pathway , genetics , pregnancy , environmental health
The risk of breast cancer is highly modifiable by diet. Breast cancer may have its origins during early mammary development, thus, the increasing popularity of soy food consumption among pregnant and breast‐feeding women and early exposure to soy protein and bioactive components through soy infant formula could have significant implications on adult incidence of this disease. Since soy protein isolate (SPI) and genistein (GEN) diets decreased chemically‐induced tumor incidence in adult female rats, dietary effects on genetic pathways underlying mammary tumorigenesis were evaluated. In rat mammary epithelial cells, SPI and GEN, relative to casein diet increased tumor suppressor PTEN and E‐cadherin expression; these effects were recapitulated in vitro by GEN. Dietary SPI also decreased lipogenic gene expression in rat mammary stromal adipocytes in vivo, which was mimicked by GEN in 3T3‐L1 adipocytes in vitro . Since Wnt signaling perturbation alters the epithelial hierarchy, MMTV‐Wnt1 mice were investigated for dietary SPI and GEN effects on mammary progenitor cell population during disease development. Female mice at weaning were assigned to CAS, SPI‐ or GEN‐based diets and mammary tumor incidence was monitored. Diet‐mediated changes in mammary transcriptional programs and in epithelial subpopulations may underlie protection from developing mammary lesions. USDA‐CRIS‐6251‐5100002‐06S; DOD‐BCRP.