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Phenethyl isothiocyanate inhibits the migration and invasion of DU145 human prostate cancer cells
Author(s) -
Hong Ji Eun,
Park Jung Han Yoon
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.897.22
Subject(s) - du145 , phenethyl isothiocyanate , cruciferous vegetables , isothiocyanate , chemistry , benzyl isothiocyanate , cancer research , apoptosis , prostate cancer , cancer cell , cancer , biochemistry , pharmacology , lncap , biology , medicine
Anti‐carcinogenic effect of cruciferous vegetables is attributed to organic isothiocyanates that occur naturally as thioglucoside conjugates (glucosinolates) in a variety of edible cruciferous vegetables such as broccoli, watercress, and cabbage. Phenethyl isothiocyanate (PITC) is a naturally occurring isothiocyanate compound that has attracted a great deal of attention due to its remarkable cancer chemopreventive properties. Previously, PITC has been reported to suppress the proliferation of human prostate cancer cells by inducing apoptosis and cell cycle arrest. In the present study, we investigated the effects of PITC on the migration and invasion characteristics of DU145 human prostate cancer cells. DU145 cells were cultured in the presence of 0 ‐ 6 μmol/L PITC. PITC inhibited migration and invasion in dose‐dependent manners. Western blot analysis revealed that PITC decreased the secretion of tissue inhibitor of metalloproteinase (TIMP)‐1, vascular endothelial growth factor and urokinase‐type plasminogen activator and increased the levels of TIMP‐2 in DU145 cells. We have demonstrated that PITC inhibits the metastasis potential of DU145 human prostate cancer cells.