Premium
The Effects of Soy Germ and Tomato Powder Containing Diets on the Growth of Dunning R3327‐H Transplantable Tumors
Author(s) -
Zuniga Krystle Erin,
Lindshield Brian L,
Erdman John W
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.897.19
Subject(s) - glycitein , soy isoflavones , daidzein , genistein , lycopene , isoflavones , food science , germ , chemistry , soy protein , endocrinology , biology , carotenoid , biochemistry , microbiology and biotechnology
A number of studies have supported the hypothesis that dietary intake of soy foods or tomato products are associated with a lower risk of prostate cancer. Soy isoflavones and lycopene are considered the primary bioactive components of soy and tomato, respectively. Soy germ, the hypocotyledon of the soybean, has a different isoflavone profile from the rest of the bean. The ratio of genistein:daidzein:glycitein in soybeans is typically 1.1:1:0.4 while it is 0.3:1:1 in soy germ. Our goal was to determine if soy germ, due to its altered isoflavone ratio, would be effective in reducing growth of Dunning R3327‐H transplantable tumors. In addition, we wanted to evaluate the potential interactive effects of tomato powder, which we have previously found to reduce tumor growth, and soy germ. Diets containing 10% tomato powder, 2% soy germ, neither, or a combination were fed to male Copenhagen rats (n=63) for approximately 24 weeks. Diets were initiated 1 month prior to receiving subcutaneous tumor implants. Tumor areas were measured weekly beginning 10 weeks after tumor implantation. Primary endpoints will include tumor area, tumor weight, urinary isoflavones, and tissue carotenoid levels.