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Comparison between Mediterranean type diet and Mediterranean fat effects in rats neoplastic lesions
Author(s) -
Pereira Paula Cardoso,
Cabrita António Silvério,
Vicente Filipa
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.897.11
Subject(s) - olive oil , mediterranean diet , dmba , mediterranean climate , pepper , cancer , zoology , food science , medicine , biology , ecology , carcinogenesis
Research had shown some implication of dietary factors in breast cancer, according to epidemiologic and experimental results. This study pretends to establish a relationship between the consumption of a diet with olive oil and a Mediterranean diet in the number and volume of breast cancer tumours. A total of 72 female rats 50 days old constituted the sample. These were divided in three groups of 24 and housed 5 in each plastic cage in a holding room under constant conditions of 22±2 °C, 55±10% humidity and a 12 h light/dark cycle. All the animals were submitted to the administration of 20 mg of 7, 12 dimethylbenzanthracene (DMBA) in olive oil, by gavages and were feed with standard diet. The Group II also received a Mediterranean‐type supplement (mixture of sardine, pepper, tomato, potato, onion lyophilized) while Group III received Olive oil in the standard food (50ml/Kg). After 150days the animals were sacrificed and the neoplastic lesions were evaluated according to the general score and the volume. In this series we can observe a non‐significant variation in the tumours number between the three groups but the tumours volume were significantly different between the groups two and three (p<0,05). The olive oil supplemented group suffered from a greater number of neoplastic lesions but the size was significantly smaller than the other groups.