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VEGF Regulates Gene Expression of Oxytocin during Pregnancy in the Cervix of Rodents
Author(s) -
Willner Weston,
Jones Fallon Anitra,
Mowa Chishimba
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.880.6
Subject(s) - oxytocin , vegf receptors , oxytocin receptor , cervix , microarray , microarray analysis techniques , gene , gene expression , biology , vascular endothelial growth factor , dna microarray , andrology , medicine , endocrinology , cancer research , cancer , genetics
Cervical remodeling is a physiological inflammatory process regulated by various factors including vascular factors. We have previously shown that VEGF regulates multiple genes involved in cervical remodeling using DNA microarray analysis, including oxytocin. Here, we validate the DNA microarray data using real time PCR. Consistent with DNA microarray data, we found that levels of oxytocin mRNA and its receptor were up‐regulated by VEGF treatment. We conclude that VEGF plays a role in regulating levels of VEGF in the cervix of rodents.