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Validation of a totally implantable blood flow, blood pressure and temperature biotelemetry system
Author(s) -
Pitsillides Koullis,
Axelsson Michael
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.812.5
Subject(s) - biotelemetry , pulsatile flow , positive displacement meter , biomedical engineering , blood flow , telemetry , pressure sensor , blood pressure , volumetric flow rate , pressure measurement , materials science , medicine , mechanics , cardiology , mechanical engineering , engineering , physics , aerospace engineering
The EndoGear totally implantable multichannel biotelemetry system was validated using standard bench‐top instruments. Although this biotelemetry system has already been used in a variety of animal models, it had not been validated over a wider range of heart rates, blood flow velocities, blood pressures and temperatures. Positive displacement pulsatile waveforms were generated using a bellows‐type pump and reference blood flow velocity was measured with a bench‐top Doppler flowmeter (Indus Instruments, 20MHz Doppler flowmeter module), while reference blood pressure was measured with a solid‐state blood pressure catheter (Millar Instruments, model SPR524). Similarly, reference temperature was measured with a calibrated temperature sensor. The pump rate, stroke volume and pressure‐chamber pressure were adjusted to simulate various physiological levels and were recorded on a computer. Temperature was varied separately, in a temperature controlled water bath, and the transmitted temperature data were recorded. The results show that the EndoGear implant is capable of accurately measure flow velocity, pressure and rate waveforms in a large physiological range. This makes it useful in studies where blood flow velocities are in the range of 5‐100 cm/s, blood pressures are in the range of 0 to 300 mmHg, heart rates are up to 250 bpm and temperatures are in the range of 0 to 50°C. The size and weight of this implant allow it to be used in animals with body weights = 2 kg. This research was supported by the Swedish Science Research Council Grants B‐DR 09856‐304 and 621‐2005‐2588