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Diets enriched in stearic acid do not depress cardiac function
Author(s) -
Thomas Candice,
Smart Eric J
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.812.18
Subject(s) - stearic acid , palmitic acid , linoleic acid , cardiac function curve , medicine , endocrinology , heart failure , chemistry , cardiac output , stroke volume , diabetes mellitus , fatty acid , heart rate , blood pressure , biochemistry , organic chemistry
Diabetes is associated with an increased risk of congestive heart failure and heart disease, however, the effects of specific fatty acids on the development of these diseases are unknown. To determine the effects of dietary fats on cardiac function in the context of diabetes, db/db mice (a model of type 2 diabetes) were fed diets enriched in palmitic, linoleic, or stearic acid (40% kcal) for 8 weeks. Left ventricular cardiac output was measured with a Millar pressure/volume catheterization system. All of the mice gained the same amount of weight, however, mice fed the stearic acid diet had significantly lower blood glucose levels and consumed less food. Mice fed diets enriched in palmitic or linoleic acid had decreased cardiac function with a heart rate of 298‐376 beats/min, cardiac output of 6568‐6759 μl/min, stroke work of 1215‐1319 mmHg*μl, dP/dt max of 4961 to 6147 mmHg/sec and dP/dt min of ‐3990 to ‐5886 mmHg/sec. In contrast, mice fed a diet enriched in stearic acid had a heart rate of 503 bpm, cardiac output of 9936 µl/minute, stroke work of 1518 mmHg*μl, dP/dt max of 7353 mmHg/sec and dP/dt min of ‐6725 mmHg/sec. The data demonstrate that palmitic and linoleic acid enriched diets negatively impacts heart function in diabetics whereas stearic acid did not. These data suggest that the type of fatty acids consumed by diabetics can differentially impact cardiac function.