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The mechanism of intramembrane proteolysis
Author(s) -
Ha Ya
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.81.2
Subject(s) - proteolysis , proteases , transmembrane protein , protease , chemistry , membrane , integral membrane protein , biophysics , microbiology and biotechnology , membrane protein , biochemistry , enzyme , biology , receptor
Intramembrane proteolytic reactions are involved in many cellular processes. These once‐considered unusual reactions are catalyzed by highly specialized integral membrane proteases. Here I describe possible mechanisms of intramembrane proteolysis, drawing lessons from the recently solved crystal structures of the membrane protease. The role of membrane compression around the protease, and how it may facilitate the unfolding of transmembrane alpha‐helices in the substrate, will also be discussed.