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Control central ‐ at the intersection of exocytic and endocytic pathways
Author(s) -
Stow Jennifer Lea
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.808.2
Subject(s) - endosome , endocytic cycle , microbiology and biotechnology , endocytosis , compartment (ship) , microvesicles , cytoplasm , immune system , biology , cell , immunology , intracellular , biochemistry , gene , microrna , oceanography , geology
Recent studies have revealed that the recycling endosome in mammalian cells receives traffic from endocytic and recycling pathways, and from exocytic or secretory pathways. It thus handles a complex mix of membrane and protein cargo, which it then sorts and deploys selectively to the cell surface or other organelles. In epithelial cells this enigmatic compartment helps to control cell polarity, cell adhesion and other functions. In immune cells, recycling endosomes control immune responses through the strategic deployment of cytokines and packets of membrane to enable phagocytosis and migration. This talk will present evidence, including imaging in live cells, to help demonstrate some of the newly discovered and widespread functions of recycling endosomes in trafficking pathways ‐ functions that centrally underpin the physiology of differentiated cells. Funding from the National Health and Medical Research Council of Australia supports this research.