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Anabolic‐Androgenic Steroids Attenuates the Reflex Muscle Vasodilatation
Author(s) -
Alves Maria Janieire N. N.,
Santos Marcelo R.,
Dias Rodrigo G.,
Akiho Cesar A.,
Laterza Mateus M.,
Rondon Maria Urbana P. B.,
Moreau Regina L. M.,
Negrao Carlos E.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.806.9
Subject(s) - microneurography , medicine , vasodilation , reflex , blood pressure , endocrinology , anabolism , forearm , baroreflex , heart rate , anatomy
We hypothesized that anabolic‐androgenic steroids (AAS) would exacerbate symphatetic nerve activity responses and attenuate muscle vasodalation responses during mental stress in young individuals. Methods Nine body builder users and 7 age‐matched body builder nonusers of AAS were studied. AAS was assessed by urine test (chromatography‐mass spectrometry). Mean blood pressure (MBP, oscillometric automatic cuff), forearm blood flow (FBF, plethysmography) and muscle sympathetic nerve activity (MSNA‐microneurography) were evaluated at rest and during mental stress (Stroop Color Word Test). Results Resting MSNA was significantly higher (28±3 vs. 20±1 bursts/min, P =.03, respectively) and forearm vascular conductance (FVC) significantly lower (2.04±0.19 vs. 2.86±0.31 units, P =.03) in user compared with nonuser of AAS. MBP was not different between groups. FVC responses to mental stress were significantly lower in user compared with nonuser (0.66±0.35 vs. 2.96±0.78 units, P =.01, respectively). MBP and MSNA responses were not different between groups. Conclusion AAS increases MSNA and reduces FBF in healthy young individuals. In addition, the reduction in muscle reflex vasodilatation during mental stress in AAS user is suggestive of impaired endothelial function in these individuals.