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Differences in Hemodynamic Responses to Stress Between Male and Female Rats
Author(s) -
Chen Fangping,
Mullenax Heather,
Sharma Puneet,
Finkel Mitchell S
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.806.5
Subject(s) - hemodynamics , medicine , diastole , diastolic function , endocrinology , cardiomyopathy , cardiology , blood pressure , heart failure
We have previously reported echocardiographic evidence of myocardial dysfunction in male rats with prenatal stress (PS) and restraint stress (R) (PS+R). We now report significant differences in hemodynamic effects of PS+R between male vs female rats. PS + R blunted both systolic and diastolic function in male rats. In contrast, PS+R enhanced systolic function and had no effect on diastolic function in female rats. PS+R blunted both systolic and diastolic responses to isoproterenol (ISO) in male rats, but enhanced the systolic and diastolic responses to ISO in female rats. No differences in baseline hemodynamics or responses to ISO were noted between male and female rats after PS alone or R alone. This cardiomyopathy model may provide insights into sex differences in behavioral and cardiovascular responses to stress in animal models and humans. Mean± SE; # p<0.05, ## p<0.01, vs Control.