Premium
CHRONIC TESTOSTERONE SUPPLEMENTATION IN ZUCKER RATS WORSEN RENAL FUNCTION IN LEAN, BUT NOT OBESE
Author(s) -
LOPEZRUIZ ARNALDO FABIAN,
ILIESCU RADU,
ZHANG HUIMIN,
RECKELHOFF JANE F.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.806.10
Subject(s) - medicine , endocrinology , testosterone propionate , testosterone (patch) , renal function , albuminuria , obesity , lean body mass , androgen , body weight , hormone
Obesity in men is associated with increases in renal disease. Androgen levels decrease in obese men, and many investigators believe this may contribute to the increased renal disease. The present study was done to test the hypothesis that chronic androgen supplementation protect against renal injury in obese rats. Male lean and obese Zucker rats, aged 24 wks, were untreated (C) or treated with testosterone propionate (5 (5T) or 10 (10T) mg/10 mm Silastic pellets implanted SQ, changed every 3 weeks) for 10 wks. Body weight (BW), GFR, albuminuria, TNF‐α, IL‐6, left ventricular index (LVI) were measured at 34 wks of age. Data shown below. compared with Lean‐C; #, compared with Obese‐C The data show that chronic testosterone decreases BW, inflammation, renal injury, LVI in obese rats, but decreases renal function and promotes renal injury in lean rats. Men with obesity may benefit from testosterone replacement.