Premium
Oxidative stress contributes to increased susceptibility to renal injury induced by mild ischemia‐reperfusion in low birth weight
Author(s) -
Ojeda Norma B
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.803.18
Subject(s) - oxidative stress , renal function , medicine , renal blood flow , renal ischemia , ischemia , low birth weight , endocrinology , reperfusion injury , urology , biology , pregnancy , genetics
The risk for renal disease is increased in low birth weight (LBW). Susceptibility to renal injury is increased in a rat model of LBW; however, the mechanism(s) involved is not clear. We hypothesize that oxidative stress contributes to LBW susceptibility to renal injury. To investigate rats were treated with vehicle (UT) or superoxide dismutase mimetic (Tempol, 30mg/k, T) starting 15 min prior to mild ischemia (15 min) and during reperfusion (2 hr). Treatment ameliorated the increase in mean arterial pressure (MAP) and renal vascular resistance (RVR), and the decrease in glomerular filtration rate (GFR), and renal blood flow (RBF), and the increase in renal oxidative stress in LBW (Table). Therefore, this data suggest that oxidative stress may contribute to increased susceptibility to renal injury in LBW. * P < 0.05 vs. Control † P < 0.05 vs. UT Counterpart