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Autonomic, cardiovascular and thermoregulatory responses to central neropeptide Y or neuromedin U in rats
Author(s) -
Tanida Mamoru,
Nagai Katsuya
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.792.6
Subject(s) - histaminergic , endocrinology , thioperamide , medicine , neuropeptide y receptor , brown adipose tissue , antagonist , heart rate , adipose tissue , neuropeptide , histamine h3 receptor , chemistry , blood pressure , histamine , receptor
Previous studies have demonstrated that neuropeptide Y (NPY) or neuromedin U (NMU) affects cardiovascular functions such as blood pressure (BP) or heart rate (HR) in rats. Here, we examined the effects of the central injection of various doses of NPY or NMU on renal sympathetic nerve activity (RSNA) and BP in urethane‐anesthetized rats. Central injection of NMU elevated RSNA, BP and HR in a dose‐dependent manner, while NPY injection reduced RSNA, BP and HR RSNA, BP and HR. In addition, central injection of NMU suppressed gastric vagal nerve activity (GVNA) and activated brown adipose tissue sympathetic nerve activity (BAT‐SNA) of anesthetized rats, and elevated brown adipose tissue temperature (BAT‐T) of conscious rats. Oppositely, NPY affected autonomic nerves and elevated the GVNA and suppressed BAT‐SNA and BAT‐T. Moreover, neither pretreatment of thioperamide, an antagonist of histaminergic H3‐receptor, or of diphenhydramine, an antagonist of histaminergic H1‐receptor, abolished increasing effects of NMU on RSNA, BP and HR However, pretreatment of thioperamide eliminated suppressive responses of RSNA, BP and HR to NPY injection. Thus, these lines of evidence suggest that NMU or NPY affects neural activities of autonomic nerves containing RSNA, GVNA or BAT‐SNA, and BP by mediating central mechanism, and possible role of histaminergic neurotransmittion in autonomic controls by NPY.