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Changes of heat shock protein 70, intracellular Ca 2+ , NO and free radicals in epilepsy rat brain tissues affected by garoderma lucidum spores
Author(s) -
Wang ShuQiu,
Kang YuMing,
Liu Lei,
Ma XiaoRu,
Wang XianGang,
Chen TingYu,
Zhang DongDong,
Liang YanFeng,
Zhang Bo
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.790.12
Subject(s) - spore , intracellular , hsp70 , epilepsy , radical , heat shock protein , brain cell , chemistry , biochemistry , biology , microbiology and biotechnology , neuroscience , gene
To investigate the effects of garoderma lucidum spores on the change of heat shock protein 70 (HSP70), intracellular Ca 2+ , NO and NOS content in epilepsy rats brain tissues. Thirty male Wistar rats at the age of 10 weeks were divided into garoderma lucidum spores group, epilepsy model group and blank control group. The result showed that NOS, NO and intracellular Ca 2+ in brain tissue of garoderma lucidum spores group were significantly lower than in epilepsy model group. The number of HSP70 positive cells was more in garoderma lucidum spores group, while there was no expression in blank contrast group. Conclusion By effectively reducing the Ca 2+ overload of neuron cell, reducing the formation and harm of NO and free radicals, and enhancing the expression of HSP70 in brain tissue, garoderma lucidum spores can weaken the damage to nerve system caused by continuous epileptic seizure.