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Aerobic exercise training increases maximal in vivo cholinergic responsiveness but not sensitivity of eccrine sweat glands
Author(s) -
Wilson Thad E.,
Monahan Kevin D.,
Kearney Matthew,
Fogelman Amy,
Sauder Charity L.,
Ray Chester A.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.788.8
Subject(s) - microdialysis , sweat , cholinergic , in vivo , aerobic exercise , acetylcholine , medicine , endocrinology , sweat gland , chemistry , biology , microbiology and biotechnology , central nervous system
Aerobic exercise training increases maximal sweat capacity and sweat responses at a given internal temperature. However, the mechanisms underlying these effects are unknown. The purpose of this study was to determine if aerobic exercise training improves in vivo cholinergic sensitivity and responsiveness of eccrine sweat glands. Eleven previously sedentary subjects were tested before and after 8 weeks of aerobic training consisting of 4 bouts of exercise per week that elicited an ~20% increase in peak oxygen uptake. In vivo cholinergic sensitivity and responsiveness were determined by dose‐response curves of acetylcholine (ACh) to sweat secretion rate on two forearm sites. ACh was administered via intradermal microdialysis while measuring cutaneous water loss (capacitance hygrometry) directly above the microdialysis membrane. Exercise training did not alter the number of cholinergic activated sweat glands or the dose‐response derived ED50 (2.0±0.1 to 2.1±0.1 ‐logM dose of ACh; P>0.05). However, the maximal response to the highest dose of ACh was greater after exercise training (0.84±0.11 to 1.16±0.21 mg/cm 2 /min, P<0.05). These data indicate that 8 weeks of aerobic exercise training does not increase in vivo cholinergic sensitivity as indicated by the ED50 but does increase maximal in vivo cholinergic responsiveness of human eccrine sweat glands. Support: HL77670, AG24420, M01 RR10732, C06 RR016499