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Apnea is exacerbated following exposure to intermittent hypoxia and is mitigated following administration of an antioxidant cocktail
Author(s) -
Yokhana Sanar,
Lee Dorothy S,
Badr M Safwan,
Mateika Jason H
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.784.1
Subject(s) - medicine , polysomnogram , intermittent hypoxia , placebo , hypoxia (environmental) , apnea , sleep apnea , randomized controlled trial , anesthesia , obstructive sleep apnea , polysomnography , oxygen , chemistry , alternative medicine , organic chemistry , pathology
Purpose To determine whether exposure to intermittent hypoxia (IH) exacerbates apnea severity and whether administration of an antioxidant cocktail (AOX) mitigates this response. Methods Two studies were completed. Ten participants with OSA completed study 1 while 5 participants completed study 2. Study 1 required two visits while study 2 required 3 visits. For both studies, a baseline polysomnogram with no intervention was completed initially. During the remaining visits of both studies, participants were exposed to IH {12‐4 minute episodes of hypoxia (PETO2‐ 50 mmHg, PETCO2 ‐ 3 mmHg above baseline)} immediately followed by a sleep study. During visits 2 and 3 of study 2 participants were administered either an AOX or Placebo (PLB) in a randomized blinded fashion. Breathing events were scored during the initial 3 hours of sleep. Results Study 1 ‐ The apnea/hypopnea index (AHI) after exposure to IH was greater compared to baseline (43.3 ± 5.3 vs. 34.6 ± 3.2 events/hr, p = 0.04). Study 2 ‐ Similar results were observed when the AHI during PLB was compared to baseline (43.4 ± 6.2 vs. 27.6 ± 7.8 events/hr, p = 0.01). In contrast, the AHI during the PLB trial was greater compared to the AHI following AOX administration (43.4 ± 6.2 vs. 31.8 ± 5.7 events/hr, p = 0.04). Conclusions Exposure to IH may lead to an increase in the AHI while administration of an antioxidant cocktail may mitigate the increase. Funding NIH (HL‐085537)