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Hypoxic regulation of early vascular and hematopoietic development in the chick embryo
Author(s) -
Sheng Guojun
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.778.1
Subject(s) - haematopoiesis , microbiology and biotechnology , biology , embryo , embryogenesis , context (archaeology) , hypoxia (environmental) , embryonic stem cell , hematopoietic cell , oxygen transport , immunology , chemistry , stem cell , oxygen , biochemistry , gene , paleontology , organic chemistry
During embryogenesis, blood and vascular systems provide essential supply of oxygen to developing organs with increasing complexity. It is not well‐understood, however, how changes in oxygen supply affect normal differentiation of hematopoietic and vascular tissues. In chickens, oxygen supply to developing organs is largely achieved via extra‐embryonically generated blood and vascular cells. The effect of hypoxia on extra‐embryonic hematopoietic and vascular differentiation is investigated with a focus on two critical periods (during primitive red cell generation and during early phase of definitive red cell generation). The roles of HIFs, aquaporins, heme and iron supply in this context will also be discussed.