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Synthesis of Some New Benzothiazol‐2‐yl‐Benzylidene‐Imines and their Antibacterial Activity
Author(s) -
Hoti Ramiz,
Vehapi Idriz,
Bicaj Muhamet,
Kalaj Vuksan,
MulliqiOsmani Gjyle
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.760.10
Subject(s) - benzaldehyde , antibacterial activity , chemistry , condensation , medicinal chemistry , condensation reaction , organic chemistry , combinatorial chemistry , bacteria , catalysis , biology , physics , thermodynamics , genetics
Nowel benzothiazol‐2‐yl‐benzylidene imines are synthesized by condensation of benzaldehydes and corresponding 2‐aminobenzothiazoles. Condensation of benzaldehyde 1a and 2‐aminobenzothiazoles 2(a,b) gave benzothiazol‐2‐yl‐benzylidene imines 3(a,b) . By condensation of 3‐nitrobenzaldehyde 1b and 2‐aminobenzothiazoles 3(a,b) , corresponding benzothiazol‐yl‐3‐nitrobenzylidene imines 3(c, d) were synthesized. The antibacterial activity of products 4(a‐d) were investigated and results were submitted for their activities against E. coli , Clebsiella and S. aureus . Compound 3d showed light bactericide activity against S. aureus . Emphatic activity against E. coli exhibited compounds 3d and 3c , whereas 3d and 3b exhibited the strongest activity against Clebsiella . In general there was a direct positive correlation between increasing concentration of the compound and antibacterial activity.