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The Effects of Acute Injections of Selective Dopamine Receptor Agonists and Antagonists on Three Models of Impulsivity in the Rat
Author(s) -
Koffarnus Mikhail,
Woods James
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.745.2
Subject(s) - impulsivity , dopaminergic , dopamine , dopamine receptor , dopamine transporter , neuroscience , psychology , task (project management) , dopamine receptor d2 , pharmacology , medicine , developmental psychology , management , economics
A role for dopaminergic transmission in the expression of impulsivity in animal models has been demonstrated. The role of individual dopamine receptors in these actions is not entirely clear, however. Sprague Dawley rats were trained to respond on one of three purported models of impulsivity: the delay discounting task, a paced fixed consecutive number schedule, or an uncertain visual discrimination task. Agonists and antagonists selective for individual dopamine receptor subtypes or compounds acting at the dopamine transporter were administered and changes in behavior were recorded. Results indicate that dopaminergic transmission is important for each of the impulsivity models examined. Furthermore, the effects of specific compounds across models are sometimes in concordance and sometimes in discordance, indicating these models are not measuring the same aspect of behavior. This research was supported by USPHS/NIDA grants R01 DA020669 and T32 DA007267.