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Validating aspects of pica response induced by oxycodone administration
Author(s) -
Batra Vinita,
Schrott Lisa M
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.742.9
Subject(s) - oxycodone , medicine , pharmacology , ingestion , opioid , pica (typography) , anesthesia , analgesic , receptor , world wide web , computer science
Oxycodone is a semisynthetic opioid analgesic. In our lab prior studies with oxycodone were accompanied by prolonged and intense oral ingestion of non‐food substances. These manifestations resemble pica behavior, an index of nausea and emesis associated with chemotherapeutic drugs and other opioids, but not to date oxycodone. To further explore this behavior, route of administration, time course and receptor mediation were investigated. The results obtained suggested that pica response is associated with oxycodone administration. Proemetic agent‐induced kaolin intake is a well established model to assess pica. To corroborate our results, we assessed kaolin intake following oxycodone administration. Adult female rats were adapted to preweighed kaolin for 2 days followed by baseline testing. Following drug or vehicle treatment, kaolin intake was assessed for 3hr for 2 days. At the end of the experiment, wet weight of stomach was measured and brain was isolated for c‐fos analysis. Oxycodone and cisplatin treatment moderately increased kaolin intake and the wet weight of stomach was elevated 2‐3 fold. Preliminary results indicate positive c‐fos staining in the area postrema and nucleus of solitary tract following oxycodone treatment. These results validate our hypothesis. Future studies will assess the mechanisms underlying the neurobiological basis of this behavior. Supported in part by LEQSF RD‐A‐19, (LA Board of Regents) and USPHS DA018181 (NIDA, NIH).