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Hepatic oxidative capacity of pre‐ and term pigs receiving parenteral docosahexaenoic and arachidonic acid
Author(s) -
Campbell Jenny A,
Martin Jessica E,
Brockson M. Elizabeth,
Melendez Krizia,
Lyvers Peffer Pasha A
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.732.1
Subject(s) - docosahexaenoic acid , parenteral nutrition , oxidative phosphorylation , gestation , arachidonic acid , medicine , zoology , endocrinology , polyunsaturated fatty acid , fatty acid , chemistry , biology , biochemistry , pregnancy , enzyme , genetics
Pigs were delivered by cesarean at 106 and 114d of gestation and umbilical catheters were placed for total parenteral nutrition. Pigs received either a control, a low DHA/AA (.3% and .6% of total lipids as DHA and AA, respectively), or a high DHA/AA (5% and 11 % of total lipids as DHA and AA, respectively) diet. Diets were administered based on piglet weight to promote moderate gain and hepatic oxidative capacity was determined after 6d. Differences were not observed in [1‐ 14 C]‐glucose (5 mM) utilization. There was a tendency for decreased accumulation in 14 CO 2 using [1‐ 14 C]‐palmitate (1 mM) as the substrate in preterm pigs receiving the high DHA/AA diet in comparison to preterm pigs receiving the low DHA/AA diet (p = 0.06). Whereas preterm pigs receiving the low DHA/AA diet had a tendency for greater accumulation of 14 C in ASP compared to pigs administered the control or high DHA/AA diet (p < 0.06), control term pigs displayed a greater accumulation of 14 C in ASP compared to pigs receiving DHA/AA supplemented diets (p < 0.05). Accordingly, the accumulation of 14 C in ASP was approximately 3 fold greater in term pigs receiving the control diet versus preterm pigs. Collectively, these findings suggest impaired hepatic oxidative capacity in preterm pigs that may be exacerbated by high DHA/AA supplementation. Salaries and research support provided by state and federal funds appropriated to The Ohio State University Ohio Research and Development Center.