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Does vitamin D status predict outcomes of experimentally‐induced muscle pain and weakness in healthy young volunteers?
Author(s) -
Peterson Catherine A,
Ring Susan M,
Dannecker Erin A
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.731.8
Subject(s) - isometric exercise , medicine , muscle weakness , vitamin d and neurology , weakness , physical therapy , eccentric , skeletal muscle , muscle strength , vitamin , surgery , physics , quantum mechanics
Vitamin D receptor's presence in skeletal muscle indicates a role in muscle function and clinical symptoms of vitamin D deficiency include muscle weakness and pain. No one has yet examined the association of vitamin D status and experimentally‐induced muscle pain or weakness in healthy people. Methods Muscle damage to the elbow flexors was induced with eccentric exercise (EE) in 27 men (mean age 22.5 yr) and 21 women (mean age 22.6 yr). Muscle pain ratings from unloaded movement and isometric contractions and peak isometric force (IF) were collected before EE and for 4 days post‐EE. Serum 25‐hydroxy vitamin D (25OHD) was assayed 2 days post‐EE. Linear regression was used to determine if 25OHD was a predictor of any outcome. Results Serum 25OHD did not predict any of the pain or strength measures. In men: R2 for pain ratings ranged from 0 to 0.02, and p‐values from 0.48 to 1.00. R2 for IF ranged from 0 to 0.02 and p‐values from 0.48 to 1.00. In women: R2 for pain ratings ranged from 0.01 to 0.21, and p‐values from 0.14 to 0.74 . R2 for IF ranged from 0 to 0.04 and p‐values from 0.41 to 0.90. Conclusion Serum 25OHD did not predict muscle pain or strength after EE‐induced muscle damage in young healthy men and women. Support: Dept. of Nutritional Sciences, Univ. of Missouri, CA Peterson; and National Institute of Arthritis and Musculoskeletal and Skin Diseases (KO1 AR050146 ) and the Univ. of Missouri, EA Dannecker.