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Plasma coenzyme Q10 levels following supplementation with various coenzyme Q10 products
Author(s) -
Bhagavan Hemmi N,
Chopra Raj K
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.729.13
Subject(s) - coenzyme q10 , ubiquinol , bioavailability , chemistry , coenzyme q – cytochrome c reductase , solubility , biochemistry , food science , mitochondrion , pharmacology , organic chemistry , cytochrome c , biology
Coenzyme Q10 (CoQ10) has a fundamental role in cellular energy production as an integral component of the mitochondrial electron transport chain. CoQ10 as a nutrient is a popular dietary supplement. Commonly available products are based upon CoQ10 in the form of ubiquinone. Products containing CoQ10 powder are poorly absorbed because pure CoQ10 is insoluble in water and has limited solubility in lipids. Our studies have shown that bioavailability can be markedly enhanced by solubilizing CoQ10 to make it water/lipid miscible. Likewise, complexing CoQ10 with γ‐cyclodextrin also enhances its bioavailability. In this report, we have examined the plasma CoQ10 response to oral ingestion of various CoQ10 products. Data show a gradual increase with increasing doses of CoQ10, and plasma concentration reaches a plateau at 2400 mg when using a tablet formulation based on crystalline CoQ10 as ubiquinone. Current evidence indicates that maximum plasma concentrations can be attained by using formulations containing solubilized CoQ10 in the form of ubiquinol. About 95% of circulating CoQ10 is present as ubiquinol regardless of the form or the amount of CoQ10 ingested, and there is evidence that the reduction of ubiquinone to ubiquinol occurs in the gut.