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Effect of Coenzyme Q10 and green tea on plasma and liver lipids, platelet aggregation, TBARS production and erythrocyte Na leak in simvastatin treated hypercholesterolemic rats
Author(s) -
Kim Yanghee,
Kang Younghee,
Kang Jungsook
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.729.11
Subject(s) - simvastatin , tbars , triglyceride , chemistry , green tea extract , cholesterol , coenzyme q10 , statin , antioxidant , medicine , green tea , endocrinology , food science , biochemistry , lipid peroxidation
Forty Sprague Dawley rats were divided into four groups and fed 0.5% cholesterol for the control; control plus 30 mg/kg simvastatin; statin plus 15mg/kg BW CoQ10 or 5% green tea powder for 4 weeks. There was no difference in plasma total cholesterol among groups, but liver total cholesterol was significantly decreased in green tea group compared with the others (p<0.05). Plasma triglyceride was significantly decreased in statin group compared with green tea group (p<0.05), and liver triglyceride was significantly decreased in green tea groups compared with the control (p<0.05). Platelet aggregation of green tea group was tended to be lower in the maximum aggregation with the higher in initial slope. Intracellular Na in green tea group was significantly higher than the control or statin group (p<0.05). Na leak in intact and AAPH treated cells was significantly decreased in statin group compared with the control (p<0.05). TBARS production in platelet rich plasma was significantly decreased in groups with CoQ10 and green tea compared with the control and statin group (p<0.05), and liver TBARS was significantly decreased in green tea group compared with statin group (p<0.05). In present study, simvastatin at dose 30 mg/kg did not show cholesterol lowering effect in rat. However, CoQ10 and green tea had antioxidant effects in rats treated with simvastatin which is known to deplete antioxidant capacity.