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Beta2‐adrenergic receptor (ADRB2) genotype is associated with acute effects and withdrawal symptoms of caffeine
Author(s) -
Day Tasevski Erica Lynne,
Cahill Leah,
Garofalo Francesca,
Eny Karen,
ElSohemy Ahmed
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.725.3
Subject(s) - caffeine , medicine , genotype , genotyping , adverse effect , anxiety , adrenergic , physiology , receptor , psychiatry , gene , biology , genetics
Twin studies suggest that genetic variation plays an important role in the interindividual variability in caffeine consumption behaviour and its acute effects and withdrawal symptoms. The objective was to determine if genetic polymorphisms of β2‐adrenergic receptor (ADRβ2), a target of caffeine action, is associated with the self‐reported acute effects experienced within 12 hours of consuming a caffeinated beverage or withdrawal symptoms experienced up to 48 hours after ceasing to consume caffeine. Subjects (196 male, 479 female) aged 20‐29 years completed a caffeine habits questionnaire and provided a blood sample for genotyping a polymorphism in the ADRβ2 gene (rs1042713, 47G>A). Caffeine acute effects and withdrawal symptoms were compared between genotypes using chi‐square tests. In this population, the frequency of the G and A alleles were 55% and 45%, respectively. Subjects with the GG genotype were less likely than those with GA or AA genotypes to experience dizziness up to 12 hours after consuming a caffeinated beverage (3%, 9%, 8%, p=0.01). The proportion of subjects who experience anxiety/nervousness up to 48 hours after ceasing to consume a caffeinated beverage was 7%, 16% and 15% (p=0.05) for the GG, GA and AA genotypes, respectively. These findings suggest that ADRβ2 genotype is associated with certain adverse acute effects of caffeine and withdrawal symptoms. Grant Funding Source Advanced Foods and Materials Network