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Vitamin D receptor (VDR) FokI polymorphisms influence body composition in physically active adolescent boys
Author(s) -
Diogenes Maria Eduarda Leão,
Bezerra Flávia F.,
Oliveira Karla J.F.,
Koury Josely C.,
Cabello Giselda K.,
Cabello Pedro H.,
Mendonça Laura M.C.,
OliveiraJunior Astrogildo V.,
Donangelo Carmen M.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.724.4
Subject(s) - foki , calcitriol receptor , lean body mass , endocrinology , medicine , vitamin d and neurology , bone mineral , body mass index , biology , chemistry , body weight , polymorphism (computer science) , genotype , osteoporosis , genetics , gene
Body composition, including bone, lean and fat mass, is known to be under complex physiologic and genetic regulation. The aim of the present study was to identify anthropometric, hormonal and genetic determinants of body composition in Brazilian physically active adolescent boys (12‐14y, n=47) by stepwise multiple regression analyze. Dependent variables were total body mineral content (TBMC), total body mineral density (TBMD), lean mass (LM) and percentage of body fat (%BF), assessed by DXA. Independent variables were chronological and bone age, weight, height, plasma testosterone and IGF‐1, serum iPTH, and VDR genotypes ( Fok I and Taq I). Results were as follows: * P <0.05, ( P <0.01, # P <0.001 Although body weight was the main factor influencing all the outcome variables, Fok I polymorphisms appeared as a modest, but significant factor influencing TBMD and %BF. Our results support the complex regulation of body composition during adolescence. VDR‐ related mechanisms are possibly involved and appear to be sensitive to Fok I polymorphisms. Financial support: CNPq and FAPERJ (Brazil).