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One year soy protein supplementation does not improve lipid profile in postmenopausal women
Author(s) -
Campbell Sara Chelland,
Khalil Dania A,
Payton Mark E,
Arjmandi Bahram H
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.722.6
Subject(s) - soy protein , postmenopausal women , apolipoprotein b , cholesterol , medicine , endocrinology , food science , blood lipids , chemistry
Based on recent evidence, there is a need to reevaluate the claim that foods containing 25 g of soy protein per serving may reduce cholesterol. The purpose of the present study was to examine if one‐year consumption of soy protein‐containing foods exerts beneficial effects on blood lipids and lipoproteins in postmenopausal women. Eighty‐seven hypercholesterolemic eligible postmenopausal women were randomly assigned to consume soy or control foods daily for one year. Serum samples were analyzed for total cholesterol (TC), LDL, HDL, triglycerides (TG), Apo A and Apo B. Sixty‐two of the 87 women completed the one year study. TC and HDL showed a trend towards increasing from baseline after one year of soy protein supplementation (230.04±6.1 vs. 242.57±6.2 mg/dl P=0.09 and 56.87±2.5 vs. 60.33±2.5 mg/dl, respectively, P=0.08). There were no significant differences in LDL or TG, however a significant increase in Apo B (105.5±5.9 vs. 120.21±5.9 mg/dl P=0.002), and a significant decrease in Apo A (189.36±10 vs. 173.21±10 mg/dl, P=.009) was seen. Our data indicate that one year soy protein supplementation does not confer cardiovascular benefits in postmenopausal women in terms of improving lipid profile. These findings as well as those from other studies lend credence for reevaluating the soy protein health claim issued almost a decade ago.