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Low‐trans fat containing phenolic compound lower plasma triglyceride and blood glucose levels in C57BL/6J mice.
Author(s) -
Cho SuJung,
Cho YunYoung,
Kwon EunYung,
Kim HyeJin,
Jeon SeonMin,
Lee KiTeak,
Choi MyungSook
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.722.17
Subject(s) - triglyceride , chemistry , medicine , endocrinology , adipose tissue , catechin , blood lipids , metabolism , lipid metabolism , cholesterol , polyphenol , antioxidant , biochemistry
Trans fats are considered as dietary risk factors for cardiovascular disease. On the other hand, phenolic compounds are considered to prevent cardiovascular disease and other chronic disease. This study investigated the effect of low‐trans fat containing phenolic compound on plasma lipid metabolism in C57BL/6J mice. We produced low trans fat (LT), LT containing monoglyceride (MG) and MG containing catechin (CT). Thirty male 4‐week‐old C57BL/6J mice were randomly divided into 3 groups; fed LT, MG, CT diet based on AIN‐76 diet (5% fat) for 12 weeks. Blood‐glucose level was significantly lower in the CT group than in the LT and MG groups. Plasma total‐cholesterol concentration in the MG group was significantly lower than in the LT and CT groups. Plasma triglyceride concentration was significantly lower in the CT group compared to the LT and MG groups. In organ weights, although there was no significance, epididymal and perirenal adipose tissue weights in the LT group seemed to be lower than in the MG and CT groups. In conclusion, the supplementation of low‐trans fat containing containing phenolic compound, catechin, was effective for lowering the blood‐glucose level and plasma triglyceride concentration in C57BL/6J mice.