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Consumption of a novel flaxseed and canola oil blend favourably improves serum lipid profiles in hyperlipidemic subjects
Author(s) -
Gillingham Leah G,
Jones Peter J
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.722.1
Subject(s) - canola , chemistry , cholesterol , hyperlipidemia , polyunsaturated fatty acid , crossover study , zoology , food science , medicine , fatty acid , endocrinology , biology , biochemistry , diabetes mellitus , placebo , alternative medicine , pathology
The objective was to analyze the lipid‐lowering potential of diets rich in a flaxseed and canola oil blend (FCO) versus canola oil (CO) compared with an average Western dietary fat profile (WD). Hyperlipidemic subjects (n=36) consumed 3 treatment diets consecutively for 28 d separated by 4 wk washouts, using a randomized crossover design. Controlled diets fed under supervision contained 35% energy (En) as fat, 70% of which was provided by FCO, CO or WD. Dietary fat profile of SFA, MUFA, PUFA omega‐6, and PUFA omega‐3 was 6, 16, 4.5, 7.5% En for FCO; 6, 22, 5, 1% En for CO; and 11.5, 16, 6, 0.5% En for WD, respectively. After 28 d, compared with WD, LDL‐cholesterol was reduced by 14% with FCO (3.07 ± 0.12 mmol/L, P<0.001) and 11% with CO (3.17 ± 0.12 mmol/L; P<0.001). Total cholesterol (TC) was reduced by 10% with FCO (5.11 ± 0.13 mmol/L, P<0.001) and 6% with CO (5.34 ± 0.14 mmol/L; P<0.001) compared with WD. Endpoint TC also differed between FCO and CO (P<0.05). FCO consumption reduced both HDL‐cholesterol by 7% (1.28 ± 0.06 mmol/L; P<0.001) and LDL:HDL ratio by 5% (2.62 ± 0.17; P<0.05) compared with WD. Triglycerides were 10% lower after FCO (1.65 ± 0.14 mmol/L; P<0.05) and 11% lower after WD (1.63 ± 0.16 mmol/L; P<0.01) than after CO (1.84 mmol/L ± 0.18). It is concluded that consumption of a FCO blend provides effective lipid‐lowering beyond that of CO in hyperlipidemic subjects. Supported by Flax and Canola Councils of Canada and ARDI.