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ANTIMICROBIAL ACTIVITIES OF SOME PYRIMIDINO AND ADENOSINO‐ 1,2,4 – TRIAZOLE‐ 3 – THIONES
Author(s) -
Rifati Arleta,
Govori Sevdije,
Bytyçi Arlinda,
Ibrahimi Hamide,
Kryeziu Fadil
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.711.2
Subject(s) - antimicrobial , candida albicans , chemistry , broth microdilution , staphylococcus aureus , antibacterial activity , 1,2,4 triazole , escherichia coli , klebsiella pneumoniae , hydroxymethyl , microbiology and biotechnology , stereochemistry , bacteria , minimum inhibitory concentration , biology , medicinal chemistry , organic chemistry , biochemistry , genetics , gene
5‐amino ‐7‐methyl‐ [1,2,4] triazolo [4,3‐c] pyrimidine ‐ 3(2H) ‐thione (1) , 5‐iminobis [1,2,4] triazolo [4,3‐c:4',3′‐f] pyrimidine ‐ 3,7 (2H,5H) ‐ dithione (2) , and 4 ‐ amino ‐ 3,4 ‐ dihydroxy ‐ 5 ‐ (hydroxymethyl tetrahydrofuran‐2‐y) ‐1,7 ‐ dihydro ‐ 8H [1,2,4] triazolo [3,4‐b] purine ‐8 (1H) thione (3) , were synthesized and evaluated for in vitro antibacterial activity against Staphylococcus aureus , Escherichia coli , Klebsiella pneumonie and Candida albicans . The assessment of the antimicrobial action of the synthesized compounds was performed using the disk diffusion and microdilution methods. During the research work of microbiological activity of these compounds (1‐3), is proved that these compounds obviously inhibit the growth of Candida albicans and Klebsiella pneumonie .