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Enhanced liver regeneration with percutaneous, pulsed, near infrared light: a pilot study
Author(s) -
Russ Tiffany Cherelle,
Beeston John,
Fisher Robert
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.699.8
Subject(s) - medicine , liver regeneration , hepatectomy , liver function , percutaneous , urology , surgery , regeneration (biology) , resection , biology , microbiology and biotechnology
Purpose The aim of this study was to determine if photobiomodulation (light therapy), on rats who receive 70% Partial Hepatectomy, enhances both rate and amount of hepatic growth after one week, compared with liver enhancement as a result of Prograf and a control group. Methods and Materials: Twenty‐four male Lewis rats were randomly selected and placed into four groups. Their diet consists of normal rat chow and a 20% glucose solution after surgery. An acclimation period of one week is required pre‐operatively. The left and medial lobes of the liver, 70% in total, will be removed or suture‐ligated. This leaves each animal with only its right and caudate lobes for metabolic function. Group one receives no light and no Prograf (Tacrolimus). The livers of these animals are expected to regenerate naturally. Group two receives one five‐minute treatment of light therapy for five days and no Prograf, group three receives a combination of the two treatments, and group four receives the hepatic stimulus (Tacrolimus). Results The results of this experiment are pending due to the need of further investigation. It is still in progress. Conclusion If the effects of this light treatment prove to be substantial, then patients who suffer from various liver afflictions and require partial hepatectomy because of these ailments can obtain a faster and less morbid recovery. (Source of Research support: NIDDK)