Premium
EGFR Mediated mTOR Activation Attenuates UVB‐Induced Apoptosis
Author(s) -
Lu Shan,
Cao Cong,
Kivlin Rebecca,
Wallin Brittany,
Sarkisian Simon,
Tamakloe Tyrone,
Bagdasarian Andrew,
Chu Wenming,
Wan Yinsheng
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.654.1
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , p70 s6 kinase 1 , apoptosis , chemistry , rptor , cancer research , microbiology and biotechnology , biology , biochemistry
mTOR acts as an important integrator of several upstream signals, including growth factors, nutrients, energy levels, and stresses. We found in this study that UVB radiation induces mTOR activation in human skin keratinocytes and both cultured mouse dendritic cells and mouse monocyte derived dendritic cells. Using various specific inhibitors and gene manipulation methods, we observed that UVB‐induced mTOR activation is dependent on EGFR‐mediated AKT activation. We also found that TSC2/mTOR, downstream of AKT, is involved in UVB‐induced S6K activation. Inhibition of EGFR, AKT and mTOR enhances UVB‐induced apoptosis. Collectively, our data suggest that EGFR mediated mTOR activation, together with its upstream signals, serve as a novel survival signal against UVB‐induced cell apoptosis.