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Effect of Autologous Platelet‐Rich Plasma on Distraction Osteogenesis of the Mandible in Rabbits.
Author(s) -
Jurjus Abdo R,
Rahme Mark,
Saghieh Said
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.650.4
Subject(s) - distraction osteogenesis , medicine , distraction , mandible (arthropod mouthpart) , intramembranous ossification , platelet rich plasma , craniofacial , bone healing , soft tissue , dentistry , bone mineral , surgery , anatomy , platelet , pathology , biology , botany , osteoporosis , neuroscience , psychiatry , genus
Distraction osteogenesis of the jaws has been used in the treatment of pediatric craniofacial deformities. Successful clinical outcome depends on a coordinated multidisciplinary treatment. Platelet rich plasma (PRP) containing growth factors extracted from autologous blood and used to increase the healing potential of bone and soft tissue has been, in addition to bone marrow cells (BMC), recently tested during distraction osteogenesis of long bones in humans. The specific aim of this research is to study the effect of PRP on bone healing after mandibular distraction in rabbits and explore future possible application in humans. Right mandibular distraction was performed in 12 rabbits divided into 2 groups of 6 each. PRP and physiological saline were injected in the callus following distraction in the tested and control group respectively. The rabbits were sacrificed after consolidation period of 45 days and the mandibles were surgically removed. Two rabbits, 1 from each group, were excluded from the study the first due to lack of adequate distraction, the second died on the 30 th day of consolidation period. Bone mineral density, radiographic analysis, mechanical properties and histological features of the lengthened bones were assessed on 10 rabbits 5 in each group. The data analysis showed a faster bone remodeling with an increase in the amount of trabeculation but no significant increase in bone mineral density and content in the experimental group in comparison to the control group. The value of this research lies in the potential acceleration of healing after mandibular distraction using PRP which is greatly needed since the mandible is usually subjected to complex functional demands.