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Prolactin family regulate vascular tone through the modulation of nitric oxide production
Author(s) -
Gonzalez Carmen,
Cuevas Pedro Martinez,
Jothar Lucia Martinez,
Manzo Pilar Larraga,
Salcedo Jimena Velarde
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.626.6
Subject(s) - endocrinology , medicine , nitric oxide , vasodilation , vasoconstriction , prolactin , endothelium , acetylcholine , angiotensin ii , stimulation , chemistry , biology , hormone , blood pressure
Prolactin (PRL) family, include, placental lactogen (PL), growth hormone (GH) and prolactin, have been associated with reproduction, lactation, differentiation and angiogenesis. However, little is known about their effects upon the vasculature. The present study was designed to determine the regulatory effects that PL, GH and PRL exert on the vascular tone and, the association with endothelial nitric oxide (NO) production, a free radical that promotes vasodilation. In this study we used isolated rat aortic rings sub maximally precontracted with phenylephrine and, treated with known vasoactive substances, acetylcholine (ACh) to elicit NO‐mediated relaxation or an endothelium‐independent relaxation NO donor, as controls. PL and GH, promoted only vasodilation‐endothelium dependent, directly associated with an increase of NO production, these actions were comparable with ACh‐induce relaxation. PRL stimulated vasoconstriction and did not modify the basal levels of NO. We are first to report, opposite actions of PL and GH with respect to PRL, in this vascular bed. Further investigation are underway in our laboratory to fully know the role of PL, GH and PRL upon vascular endothelium, which may contribute to the understanding and control of cardiovascular pathologies, like coronary ischemia, that colud resolve through stimulation of vasodilaton. Supported by PROMEP /103.5/07/2574 and CONACyT 84576.