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Renin‐Angiotensin System Blockade Improves Skeletal Muscle Glucose Uptake In Burn Injury
Author(s) -
Kasper Sherry Oden,
West Lori Gail,
Desai Jayashree,
Phillips Erin,
Benavides Jeshurun,
Lepard Jacob,
Wayne Michelle,
Enderson Blaine L,
Daley Brian J,
Karlstad Michael D
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.626.17
Subject(s) - losartan , medicine , endocrinology , burn injury , glucose homeostasis , insulin resistance , insulin , renin–angiotensin system , angiotensin ii , blockade , glucose uptake , homeostasis , chemistry , receptor , surgery , blood pressure
Insulin resistance after burn is associated with alterations in postreceptor insulin signaling and abnormal glucose homeostasis. We have previously shown that renin‐angiotensin system blockade using losartan, an AT 1 receptor blocker, improves insulin signaling and glucose tolerance in burn injured rats. In this study, we examined the effects of losartan on 2‐deoxy‐glucose uptake into the soleus muscle of burned rats. A 30% body surface area burn was induced by immersion of the dorsum into 90ºC water for 15s. Sham burned rats were immersed in 23ºC water. Losartan (30 mg/kg/day) or placebo (water) was given by gavage for three days post‐burn resulting in sham burn (n= 8), burn placebo (n= 8) burn losartan (n= 8). Insulin (100 nM) stimulated glucose uptake was impaired in the soleus muscle of burn placebo animals as determined by 2‐deoxy‐glucose uptake, in vitro (77% decrease compared with sham). However, losartan treatment completely reversed this effect returning the uptake to the level of the sham burn animals. This suggests that the renin‐angiotensin system is involved in the insulin resistance of skeletal muscle that occurs in burn injury.