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High salt diet during pregnancy: effects on the renin ‐angiotensin‐aldosterone system in adult male offspring of Wistar rats
Author(s) -
Ramos Débora Rothstein,
Costa Nauilo L.,
Oliveira Ivone B.,
Lopes Karen L.,
Heimann Joel C.,
Furukawa Luzia NS.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.626.12
Subject(s) - offspring , medicine , endocrinology , pregnancy , renin–angiotensin system , weaning , aldosterone , angiotensin ii , biology , blood pressure , genetics
Objective To study the effect of high salt intake during pregnancy on the renin‐angiotensin system, COX‐2 and nNOS in adult male offspring of Wistar rats. Methods and Results Female Wistar rats were fed with normal salt ‐ NSD (1.3%), high salt 1 ‐ HSD1 (4.0%) or high salt 2 HSD2 (8.0% NaCl) diet during pregnancy. Dams after delivery and offspring after weaning were fed NSD. Table (mean ± SEM): Parameters analyzed in 12 week‐old offspring. * p <0.05 vs. NR Conclusion High sodium intake during pregnancy induces changes in renal renin‐angiotensin‐aldosterone system, COX‐2 and nNOS in male offspring of Wistar rats. Financial Support FAPESP