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PICOT, a novel monothiol glutaredoxin, plays a critical role in postembryonic growth and cardiac function in mice under nutritional perturbation
Author(s) -
Cheng NingHui
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.617.8
Subject(s) - medicine , endocrinology , embryo , biology , wild type , oxidative stress , cardiac function curve , microbiology and biotechnology , biochemistry , gene , mutant , heart failure
PICOT ( P rotein Kinase C‐ I nteracting C ousin o f T hioredoxin) is a newly identified monothiol glutaredoxin. In the present study, we demonstrated that MmPICOT had conserved functions in cell proliferation and response to oxidative stresses. Furthermore, disruption of MmPICOT in mice caused embryo lethal. In Picot +/− mice, early postembryonic growth was indistinguishable to wild type littermates, but Picot +/− mice did show significantly less in body weight and lean mass than that of wild type littermates when mice were ageing. Picot +/− mice on chow diet displayed distinct difference in intraventricular septal wall thickness and LV posterior wall thickness at end‐systole in comparison to wild type littermates, but cardiac output in those Picot +/− mice remained similar to wild type littermates. However, under chronic dietary fat intake, Picot +/− mice had significant decrease in ejection fraction and fractional shortening, suggesting impaired cardiac function in those Picot +/− mice. Together, these results suggest that PICOT is essential in embryo development and may also play a critical role in postembryonic growth and heart function, particularly under oxidative stress and nutritional perturbation.