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Decreased focal cerebral ischemic injury in Tek‐Grin1 KO mice
Author(s) -
Alexander Jonathan Steven,
Yilmaz Gokhan,
Granger D Neil,
Minagar Alireza,
Jennings Merilyn H
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.614.1
Subject(s) - nmda receptor , stroke (engine) , medicine , receptor , knockout mouse , in vivo , middle cerebral artery , occlusion , anesthesia , ischemia , biology , mechanical engineering , microbiology and biotechnology , engineering
Prior reports by our and other labs suggests that NMDA receptors in vascular endothelial cells mediate stroke‐like forms of injury in vitro, but equivalent demonstrations of vascular NMDA receptor participation in stroke in vivo are controversial. To overcome these problems, NMDAR1 (Grin1)/Tek (Tie‐2)‐ Cre mice, a mouse endothelial‐selective knockout for NMDAR1 were used in a model of stroke, middle cerebral artery occlusion (MCAO). Tek‐Grin‐/‐ mice showed significantly less neurological injury (p<0.05)and infarct size (p<0.05) measured at 24h (after 1h of middle cerebral artery occlusion). These results provide additional evidence in support of the role of NMDARs in post‐ischemic vascular stress in stroke.