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Correlation between acute stroke and microalbuminuria. Potential role of underlying systemic microvascular endothelial disease
Author(s) -
Toth Peter,
Koller Akos,
Marko Lajos,
Halmai Richard,
Bosnyak Edit,
Szapary Laszlo,
Komoly Samuel,
Nagy Judit,
Wittmann Istvan
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.613.9
Subject(s) - microalbuminuria , medicine , renal function , stroke (engine) , kidney disease , cardiology , creatinine , sss* , proteinuria , kidney , urology , mechanical engineering , engineering
We hypothesized that ischemic stroke is a manifestation of a systemic microvascular endothelial disease, which is thought to be characterized by microalbuminuria (albumin/creatinine: male patients: 2.5‐25; female patients: 3.5‐35 mg/mmol). Thus in patients with acute ischemic stroke (n=100) HPLC was used to measure urinary albumin/creatinine and glomerular filtration rate was estimated (eGFR) by the MDRD formula to characterize kidney function. To assess the severity of stroke the Scandinavian Stroke Scale (SSS) and the National Institute of Health Stroke Scale (NIHS) were used. We have found that 54.1% of stroke patients with normal kidney function (eGFR above 90 ml/min/1,73m2) had microalbuminuria. In addition, 69% of stroke patients with microalbuminuria had decreased kidney function, as well (eGFR below 90 ml/min/1,73m2). The severity of microalbuminuria correlated significantly (p<0,01) with the severity of stroke (SSS: NM: r = ‐0,38; HPLC: r = ‐0,35; and NIHS: NM: r = 0,24; HPLC: r = 0,24). We suggest that both ischemic stroke and microalbuminuria are likely a consequence of a systemic vascular endothelial disease and thus it seems to be important to assess microalbuminuria and kidney function in all stroke patients. Grants: Hungarian Sci. Res. Funds/OTKA T48376, K71591, F68638; Health Sci. Council/ETT 364/2006, Hungarian Neuroimaging Foundation, Am. Heart Assoc. Founders Aff. 0855910D, USA