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Effect of physical training on hind limb blood flow with femoral artery occlusion in pigs
Author(s) -
Terjung Ronald L,
Yang Hsiao Tung,
Bowles Douglas K,
Laughlin M. Harold
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.608.6
Subject(s) - medicine , external iliac artery , femoral artery , collateral circulation , blood flow , artery , occlusion , aorta , cardiology , anatomy
Physical training (PT) is an important regimen for intermittent claudicants. To develop collateral circuit supporting the large muscle mass in large mammals, requires development of large caliber conduit vessels. To study whether PT enhances to develop large collateral conduits, male Yucatan pigs (35 kg) received femoral artery occlusion. Flow probes were placed on each external iliac artery and the pigs were given a stress test each wk for eight wks (@1‐5 mile/h). BP in the thoracic aorta was monitored. Pigs were either kept in cage activity (Sed) or ran on treadmill @ 3.5 mi/hr for 35 min/d, for 8 wks (Tr). BP during exercise declined (35%) after PT. Peak BF through the iliac artery observed increased in both Sed and Tr pigs similarly over 8 wks (643±83 to 913±26 ml/min). This increase in BF is similar to the 250±25 ml/min measured in the unobstructed contralateral femoral artery during the same exercise intensity. Thus the increased BF was attributed to collateral flow via the newly formed collateral vessels that were later verified angiographically. BF though the iliac artery remained modestly elevated post‐exercise, compared to the non‐obstructed contralateral iliac artery, characteristic of an ischemic hyperemia response. Our findings demonstrate that a robust collateral vessel development occurs following occlusion of the supply vessel in a large mammal. Supported by NIH P01HL 52490