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Longevity is associated with increased vascular resistance to metabolic stress in P. leucopus
Author(s) -
Ungvari Zoltan,
Labinskyy Nazar,
Pacher Pal,
Mukhopadhyay Partha,
Podlutsky Andrej,
Austad Steven,
Csiszar Anna
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.595.2
Subject(s) - peromyscus , oxidative stress , longevity , biology , rodent , inflammation , endocrinology , immunology , zoology , ecology , genetics
The oxidative stress hypothesis of aging predicts that cells of long‐lived species exhibit superior resistance to oxidative stress. We tested this hypothesis using two taxonomically related rodents, the white‐footed mouse (Peromyscus leucopus) and the house mouse (Mus musculus) that show a more than two‐fold difference in maximum lifespan potential (8.2 and 3.5 years, respectively). In P.leucopus aortas steady‐state endothelial O2.‐ and H2O2 production and ROS generation by mitochondria were less than in M.musculus vessels. Furthermore, vessels of P.leucopus were more resistant to the pro‐oxidant effects of HG. In M.musculus arteries HG elicited significant up‐regulation of inflammatory markers (TNFá, IL‐6, ICAM‐1, VCAM and MCP‐1). In contrast, the pro‐inflammatory effects of HG were blunted in P.leucopus vessels. Thus, increased lifespan potential in P.leucopus is associated with a decreased cellular ROS generation and increased resistance to the pro‐oxidant and pro‐inflammatory effects of metabolic stress, which accord with the predictions of the oxidative stress hypothesis of aging