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Monocyte integrin CD11c/CD18 is a functional biomarker for risk of cardiovascular disease
Author(s) -
Gower R Michael,
Wu Huaizhu,
Knowlton Anne A,
Ballantyne Christie M,
Simon Scott I
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.593.7
Subject(s) - hyperlipidemia , cd11c , medicine , postprandial , monocyte , endocrinology , biomarker , meal , myocardial infarction , cd18 , biology , integrin alpha m , diabetes mellitus , insulin , biochemistry , receptor , gene , phenotype
Atherosclerosis is a systemic disease in which hyperlipidemia, hemodynamics, and inflammation superpose to enhance monocyte recruitment to distinct arterial regions. This in turn leads to plaque formation, vascular occlusion, and myocardial infarction. Recently we reported that integrin CD11c/CD18 cooperated with VLA‐4 in monocyte recruitment in apoE‐/‐ mice fed a high fat diet. Here we investigate if CD11c correlates with risk factors of cardiovascular disease (CVD). 60 healthy human volunteers (50% male, age 19‐66) were asked to fast overnight for 10 hours. Blood was drawn and donors were fed a 45% fat meal. 3.5hrs postprandial, donors returned for a second blood draw. Blood glucose, total cholesterol, HDL, triglycerides, and apolipoprotein B content were measured fasting and after the meal. Triglycerides increased significantly, but other constituents were unchanged. Resting and MCP‐1 stimulated levels of CD11c on monocytes were significantly increased after the fatty meal. Donors over 35yrs expressed significantly more CD11c compared to the younger group, which correlated with higher BMI and total cholesterol and lower HDL. We conclude hyperlipidemia associated with a high fat meal and age can upregulate monocyte CD11c, suggesting this adhesion molecule may serve as a biomarker for those at risk of CVD. This work was supported by HL082689 to S.I.S. and T32 HL086350‐01A1 to R.M.G.