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Effect of Antioxidant Supplements on Normal and Atherogenic Dieted Rabbit Fibrinolytic Activity
Author(s) -
Beard Elizabeth Letitia,
Sokolowski Joseph
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.593.5
Subject(s) - medicine , endocrinology , vitamin e , cholesterol , platelet , antioxidant , chemistry , biochemistry
Ten New Zealand strain rabbits were fed Normal Diet(ND) ( Purina Rabbit Chow‐PRC) vs ten fed Atherogenic Diet(AD) (2% cholesterol, 6% corn oil and 92% PRC). Five animals / diet received the vitamin supplement (VS)=Vitamin C (2gms/day) + Vitamin E (80 IU/day in 0.25 ml. soy lecithin). In 8 weeks, Plasma Fibrinolytic Activity(PFA) was 24.4% in ND+VS vs 14.67% in ND‐VS animals. AD +VS had 16.5% and AD‐VS rabbits 10.4% PFA. In 16 weeks, PFA values were 28.8% in the ND +VS vs 28.8% for ND ‐ VS animals and the AD values were 29.8% +VS and 27.3% ‐VS. FA in homogenized blood platelets was 43.6% in the ND+VS, 35.2 % in ND ‐VS , 43.0% in AD +VS and 42.2% in AD‐VS platelets . Blood Cholesterol values after eight weeks were comparable in the two ND groups. The AD +VS had 915 mg% cholesterol vs 1220mg%for the AD‐VS group. After 16 weeks , cholesterol values in the AD+VS group were slightly above the AD ‐VS group. Plasma and platelet phospholipid levels were not significantly altered by the VS. Addition of the antioxidants to the diet significantly increased FA in the blood plasma and platelets of ND animals. VS slightly increased these values in AD rabbits . At autopsy, the AD+VS group had reduced atherogenic plaque in their aortae compared to AD ‐VS animals.