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Effects of extended access and withdrawal on the reinforcing strength of cocaine using a cocaine vs. food concurrent‐choice procedure in rhesus monkeys
Author(s) -
Banks Matthew L,
Negus S Stevens
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.588.10
Subject(s) - cocaine use , psychology , self administration , medicine , anesthesia , psychiatry
Drug withdrawal may increase the reinforcing strength of some classes of abused drugs. However, the effects of cocaine withdrawal on the reinforcing strength of cocaine have produced divergent results. This study examined effects of graded periods of cocaine access and withdrawal on the relative reinforcing strength of cocaine using a cocaine vs. food concurrent‐choice procedure. Cocaine (0 ‐ 0.1 mg/kg/inj) and banana pellets were available under a concurrent‐choice schedule during daily 2‐hr sessions (n=4). Cocaine maintained a dose‐dependent increase in cocaine choice. Subsequently, extended access to cocaine was introduced via availability of 0.1 mg/kg/inj cocaine under a FR 10/ Time Out X schedule during 21hr sessions that followed daily choice sessions. The degree of access was manipulated by varying the time‐out (30, 15, 7.5 min). Extended access with each TO was introduced for 1 week, followed by at least one week of withdrawal. Cocaine intake increased as TO decreased, and peak intake was approximately 11 mg/kg/day. Neither extended cocaine access nor withdrawal altered cocaine choice. Thus, under these conditions, extended cocaine access and withdrawal failed to alter the relative reinforcing strength of cocaine. Research supported by P01‐DA14528 from NIH/NIDA.