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COMBINATION OF HIGH SALT INTAKE WITH DIABETES IN AUTONOMIC MODULATION OF THE CARDIOVASCULAR SYSTEM IN RATS
Author(s) -
Farah Vera,
Fiorino Patricia,
Yokota Rodrigo,
Araujo Iara Cristina,
Fonteles Manassés Claudino
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.578.16
Subject(s) - diabetes mellitus , medicine , blood pressure , heart rate variability , analysis of variance , endocrinology , type 2 diabetes , pulse pressure , heart rate , cardiology , zoology , biology
The purpose of this study was to evaluate the cardiovascular function induced by high salt intake in diabetic rats. Male Wistar rats (n=6, each group) were divided in: Control (CG), without treatment; Diabetic (DG), induced by streptozotocin (STZ 50mg/kg, 21 days) and Diabetic and salt (DSG), diabetes induced by STZ and salt added to the drinking water (1%) during the last 10 days. Arterial pressure (AP) was recorded and processed with a data acquisition system. Systolic arterial pressure (SAP) and pulse interval (PI) time series were submitted to autoregressive spectral analysis to determine SAP and PI variability in time (variance) and frequency domains. AP was reduced in DG (95±2 mmHg) and increased in DSG (119±4 mmHg vs ), when compared with CG (106±1 mmHg). Heart rate was reduced in DG (286±10 bpm vs 352±5 bpm, CG). In DG, there was a decrease in SAP variance (3±0.6 mmHg2 ) and its low frequency domain (LF) (1±0.2 mmHg2 ) when compared with CG (9±0.6 and 6±1 mmHg2 , variance and LF, respectively). High salt intake restored the SAP variance and its LF domain in DSG. Salt intake associated with diabetes increased PI variance (41±8 vs 12 ± 1 ms2, DSG vs CG) and both frequency domains, LF (3.8±2 vs 1.7 ±1 ms2, DSG vs CG) and high frequency (28±7 vs 8 ±1 ms2, DSG vs CG). The key findings of the present study were that high salt intake associated with diabetes modulate the autonomic input of the cardiovascular system induced by diabetes.