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Dietary Factors related to Insulin Resistance in Overweight Mexican Pregnant Women
Author(s) -
Perez Marcela,
De Haene Jessica,
Casanueva Esther,
Parra Adalberto,
Havel Peter,
King Janet
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.554.3
Subject(s) - overweight , insulin resistance , medicine , gestational diabetes , endocrinology , gestation , pregnancy , insulin , polyunsaturated fatty acid , impaired glucose tolerance , population , homeostatic model assessment , obesity , obstetrics , fatty acid , biology , environmental health , biochemistry , genetics
Insulin resistance (IR) increases during late pregnancy enhancing the risk of impaired glucose intolerance (IGT) or gestational diabetes mellitus (GDM). Overweight and obese women are at risk for IGT or GDM. Diet is used to treat of GDM, but the relationship between maternal diet and IR in pregnancy is not clear. Objective: To identify dietary factors that influence IR and post glucose load insulin sensitivity (IS) in overweight/obese Mexican women during mid and late gestation. Methods Thirty‐seven overweight Mexican women (BMI: 28.7+4.2) were studied. Nutrition counseling was given at baseline (20 wks gestation). Dietary intakes were estimated from three 24‐hr recalls done between 21 and 28 wk gestation. A 100g oral glucose tolerance test (OGTT) was performed at 28wk. The Homeostasis Model Assessment (HOMA‐IR), the Matsuda/DeFronzo Insulin Sensitivity Index and the insulin area under the curve (AUC) were determined. Results Dietary polyunsaturated fat (PUFA) intake explained 12% of the variability in HOMA‐IR at 28 wk (p<0.05), and the % energy from protein explained 12% of the variability in the insulin AUC (0.05); none of the dietary variables were related to IS. Conclusion In this population, HOMA‐IR declined by 4% for each gram of PUFAs consumed per 1000 kcals/day suggesting that pregnant women at risk for IR and GDM should be encouraged to increase their PUFA intake. Partially supported by UC Mexus