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Dried Plum Suppresses the OVX‐Induced Increase in Bone Turnover in Adult Osteopenic Ovariectomized Rats
Author(s) -
Lim Yin F,
Wang Yan,
Rendina Elizabeth,
Bu So Young,
Cullen Diane M.,
Marlow Denver,
Clarke Stephen L.,
Lucas Edralin A.,
Smith Brenda J.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.553.8
Subject(s) - ovariectomized rat , endocrinology , osteopenia , medicine , bone remodeling , bone resorption , osteoporosis , chemistry , bone density , resorption , estrogen , bone mineral
Dietary supplementation with dried plum (DP) has been shown to reverse bone loss in osteopenic animals, but our understanding as to how bone metabolism is altered remains unclear. To address this issue, 6‐month‐old female Sprague Dawley rats (n=84) were either sham‐operated or ovariectomized (OVX) and assigned to: Sham‐ control diet (AIN‐93M), OVX‐control diet, OVX‐5% (w/w) DP, OVX‐15% DP, OVX‐25% DP or the positive control OVX+PTH (80 μg/kg/d x 5 days/wk). Post‐operatively, rats were maintained on control diet (6 wks) until osteopenia was confirmed, followed by 6 wks of treatment. DP (15% and 25%) improved vertebral bone density (p<0.05) compared to the OVX group, but did not restore bone density to that of the sham group. μCT analyses of the vertebral body demonstrated that trabecular bone volume, number, thickness were decreased (p<0.05) by OVX, and DP enhanced these structural properties. Finite element analysis revealed partial restoration of bone strength and stiffness by DP. All doses of DP decreased the OVX‐induced increase in bone turnover based on serum PINP and the 15% and 25% reduced bone resorption. In contrast, PTH maintained the increase in bone turnover and resorption associated with OVX. These data suggest that DP's effects on bone are mediated by slowing bone turnover and further studies should investigate how these effects are mediated. (Supported by USDA Grant #2006‐35200‐17383)