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Does dietary resistant starch mimic the effects of food restriction on the aging related co‐morbities?
Author(s) -
Martin Roy J,
Keenan Michael J,
Tulley Ricard T,
Raggio Anne M,
Shen Li,
McCutcheon Kathleen L,
Ingram Donald,
Zhou Jun
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.548.7
Subject(s) - resistant starch , insulin resistance , starch , oxidative stress , biochemistry , digestion (alchemy) , biology , chemistry , food science , insulin , endocrinology , chromatography
It is well established that caloric restriction attenuates many aging processes and increases lifespan in numerous species. Resistant starch (RS) is a dietary carbohydrate formed by non‐fiber glucose polymers that resist digestion in the small intestine and is fermented by bacteria in the large intestine to produce short chain fatty acids. Although the mechanism remains unclear, dietary resistant starches have been shown to decrease plasma cholesterol and triglycerides, increase insulin sensitivity, decrease fat storage, and produce anti‐cancer effects in humans. We propose that dietary RS will mimic the effects of food restriction on aging and life span. In this study, we report on the mining of a microarray data generated from cecal cells from rats fed control and RS diets using Applied Biosystems rat genomic chips and PANTHER software and validations by qPCR. The focus of this study was on pathways known to be involved in anti‐aging mechanisms. For example, glutathione S‐transferase, which is involved in detoxification pathways, is elevated 10‐fold by RS. The following pathways were found to be up‐regulated by RS: apoptosis, oxidative stress and p53. The following pathways were down regulated by RS: inflammation, and toll‐like receptors. These observations provide guidance for future studies on the impact of a resistant starch diet on anti‐aging mechanisms. Supported by National Starch and LSU AgCenter.