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A preliminary report on age‐related elevations of saliva advanced glycation endproducts (AGEs) and arNOX
Author(s) -
Gao Ling,
Zhu JiaShi
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.547.2
Subject(s) - saliva , glycation , diabetes mellitus , oxidative stress , medicine , biomarker , skin aging , physiology , endocrinology , biology , dermatology , biochemistry
Literature reported elevation of skin AGEs during aging (J Clin Invest 91:2463, 1993). Plasma AGEs did not show the same relationship, but relate to diabetes and other diseases (Diabetes Care 22:1543, 1999; Chin J Gerontol 26:725, 2006). We tested saliva AGEs in this preliminary study, as well as ecto‐arNOX (aging‐related NADH oxidase) that is a potential biomarker of excessive cell oxidative stress and propagates the aging cascade to other cells. Saliva samples were collected in the early afternoon (1‐2 pm) after lunch from 11 volunteers of 20 to 74 yrs‐old. Saliva AGEs fluorescence (ex. 360nm, em. 450nm) was increased with aging after adjusted with life styles (smoking and drinking) (r=0.732, p=0.016). Increases in saliva arNOX activity was found with aging (r=0.676, p=0.022), showing a good correlation with saliva AGEs (r=0.859, p=0.001). This preliminary study with a limited sample size suggests that saliva AGEs fluorescence and arNOX activity may increase possibly correlatively during aging, and serve as potential clinical markers for aging studies. This needs to be further confirmed in a larger population and with more AGEs measurements.